webmd.comThe horizontal axis represents the H3 sequence and the vertical axis represents the amino acids by which the corresponding row is mutated. Then, the goal proteins or subdomains of them containing the target lysine will be produced recombinantly and the methylation additionally tested at protein degree. A) Discrimination factors of NSD1 for the recognition of amino acid residues on the positions subsequent to the goal lysine (K36 in the experiment proven here).

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